An international mathematician research team has proposed a new method to understand the biological mystery of a stumped molecular biologist. They used a mathematical model to calculate the mechanism of action of a small molecule called microRNA (microRNA, miRNA).
For now, scientists have proposed several different and sometimes conflicting theories to explain the way in which miRNA regulatory proteins are produced, because even small changes in experimental conditions can cause large changes in results.
Professor Alexander Gorban from the University of Leicester in the UK and Andrei Zinovyev from the Curie Institute in Paris, France, worked with biologists Nadya Morozova and Annick Harel-Bellan to construct a mathematical model. , It makes different performance under different conditions. Their research findings were published online in RNA Journal on July 31, 2012.
Professor Gorban said, “We found that the seemingly very different mechanism is actually a relatively simple biochemical reaction in different environments. Our model suggests that miRNA may play many roles in protein production at the same time, and according to experiments Conditions, it functions in a stable and efficient manner, that is, regulates the rate of protein production. If this model is accepted, we will be able to take positive steps to determine what the main mechanism of miRNA work is. This will Helps resolve the debate that has been going on for ten years in understanding how miRNAs actually work. "
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