Abstract: Artificial skin is a skin substitute artificially developed in vitro and should have good breathability similar to skin. In this paper, some artificial skin was used as the test sample, and the oxygen permeability was tested by Labthink OX2/230 oxygen transmission rate test system. The test process, test principle, equipment parameters and scope of application were introduced. This provides a reference for the development of artificial skin and the detection of its properties.
Keywords: artificial skin, breathability, oxygen transmission, oxygen transmission rate, oxygen transmission rate tester, isobaric method
1, meaning
Artificial (work) skin is a skin substitute that is artificially developed in vitro. It is divided into temporary alternative artificial skin and permanent artificial skin according to the way of bonding with damaged skin. It is used to repair and replace defective skin tissue, especially It has a remarkable effect in the treatment of burns and burns, avoiding the transplantation of healthy skin from patients, and the phenomenon of “demolition of the east wall and the repair of the western wallâ€, and the compatibility with the human body is good, and generally no immune rejection occurs. reaction. In order to realize the effect of artificial skin on infection and promoting the growth of connective tissue during skin grafting, it is required to have similar gas permeability as human skin to meet the environmental conditions of skin regeneration and prevent skin ulceration. Therefore, for artificial skin, good breathability is one of the basic properties that must be considered during its development and use.
Figure 1 artificial skin
2, test samples
The test samples used in this test are artificial skins of a certain type.
3. Testing basis
At present, the commonly used detection methods for the oxygen permeation of film and sheet samples are pressure difference method and equal pressure method. Among them, the method standard for the differential pressure method is GB/T 1038-2000 "plastic film and sheet gas" The permeability test method for permeability test method, the standard for which the pressure equalization method can be referred to is GB/T 19789-2005 "Case measurement method for plastic film and sheet oxygen permeability test of packaging materials". In this test, the oxygen permeability of artificial skin samples was measured by the principle of isobaric pressure.
4, testing equipment
In this paper, the OX2/230 oxygen transmission rate test system is used to test the permeability of the sample. The equipment is independently developed by Jinan Languang Electromechanical Technology Co., Ltd.
Figure 2 OX2/230 oxygen transmission rate test system
4.1 Principle of the test
The oxygen transmission rate is measured by the volume of oxygen per unit area of ​​the sample per unit time. The upper and lower test chambers of the equipment are separated by clamped specimens. When tested by the isostatic method, the pressure on both sides of the specimen remains the same. One side of the specimen (the upper test chamber) flows with high purity oxygen, and the other One side (lower test chamber) flows with high-purity nitrogen, so that a certain concentration difference is formed on both sides of the sample. According to the gas diffusion principle, oxygen will permeate from the upper test chamber through the sample to the lower test chamber, and The flow of nitrogen is carried to the sensor for analysis of the oxygen concentration to obtain the oxygen transmission rate of the sample. The device can also be used for the testing of container samples. During the test, the inside of the container flows with high-purity nitrogen, and the outside of the container flows with oxygen or air. The other principles are the same as those for the film samples.
4.2 Equipment parameters
OX2/230 oxygen transmission rate test system (Labthink), with ultra-high precision, independent three-chamber structure can test three identical or different samples at the same time, the temperature control range is 15 ° C ~ 55 ° C, the humidity control range is 0% RH, 35% RH ~ 90% RH, the film oxygen transmission rate test range is (0.01 ~ 6,500) cm3 / m2 · 24h, and can be extended to (0.07 ~ 6,5000) cm3 / m2 · 24h. The system also expands to test containers with oxygen transmission rates ranging from 0.0001 to 60 cm3/(pkg·d). The system can realize the high-efficiency system of 10 instruments connected in parallel and 30 samples simultaneously tested.
4.3 Scope of application
The instrument meets various national and international standards of ISO 15105-2, GB/T 19789, ASTM D3985, ASTM F2622, ASTM F1307, ASTM F1927, JIS K7126-2, YBB 00082003, and can meet various soft plastics under different temperature and humidity environments. Membrane, paper-plastic composite film, co-extruded film, aluminized film, aluminum foil, aluminum foil composite film and other materials, and oxygen barrier test of various materials, and can expand the test of bottles, bags and cans made of various materials. , oxygen permeability test of boxes and barrels.
5, the test process
(1) A sample having a diameter of 1.5 cm was randomly cut from the surface of the artificial skin.
(2) Apply a layer of vacuum grease around the lower test chamber, place the sample on the lower test cavity, make the surface of the sample free of wrinkles or creases, install the test cavity, and let the greased O-ring contact the test sample. The sample is clamped between the upper and lower test chambers.
Figure 3 Special fixture for the test process
(3) Run the equipment software, set the test temperature, humidity, test mode and other parameter information, click the test option, the test starts.
(4) Adjust the flow control valve so that the humidity in the upper and lower chambers reaches the set value. The equipment is tested according to the set conditions and the test results are calculated and displayed after the test is completed.
6, test results
The artificial skin sample tested in this test had an oxygen transmission rate of 18831.0417 cm3/(cm2·24h).
7. Conclusion
Artificial skin is an effective means to replace human skin for the treatment of burns, burns, etc. Good breathability is one of the important performance requirements for its medical effects. In this paper, the oxygen transmission rate of certain artificial skin is detected by OX2/230 oxygen transmission rate test system. The operation of the equipment is simple, the test process is highly intelligent, and the test results are highly accurate and reproducible. This method can be used. Accurately test the breathability of artificial skin. Labthink is a high-tech enterprise integrating R&D, production and packaging inspection services for packaging inspection equipment. It is committed to providing high-end, intelligent and cost-effective packaging inspection equipment and accurate, efficient and intimate packaging inspection services to customers around the world. At present, the customers that have been served include food, medicine, health products, daily chemical companies and other third-party testing institutions, universities, research institutes and other organizations from all over the world. Learn about the relevant testing equipment and services, you can log in to view. The more you understand, the more trust! Jinan Languang Electromechanical Technology Co., Ltd. is looking forward to enhancing technical exchanges and cooperation with enterprises and institutions in the industry!
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