Guide
Recently, the research team at Cologne and Bonn University in Germany discovered how protein aggregation affects the glucose metabolism process regulated by insulin receptors, triggering body aging.
Our longevity depends not only on our way of life, but also on our genetic material. The genetic program in which insulin receptors regulate plays an important role. Recently, the research team at the University of Cologne and Bonn in Germany discovered how protein aggregation affects this genetic process, triggering body aging. Related articles were published in the April 21 issue of Cell.
Insulin receptor is an expected life brake
In the early stages of our evolution, sugar intake is closely related to the length of life, and in the relationship between sugar and life, insulin plays a crucial role. By binding to cell surface receptors, insulin can rapidly and efficiently regulate blood sugar levels, but many survival-related processes are shut down at the same time. This is not necessary for the body when the food supply is sufficient, although this is a long-term reduction in life expectancy. Insulin receptors are like brakes of life expectancy, and experimental animals inactivated by insulin receptors actually live longer than normal experimental animals.
But how does insulin receptors usually remain in our cells and tissues? A recent study by scientists at the University of Cologne and Bonn focused on this fundamental question.
Anti-aging effect of CHIP protein
The researchers found that a protein called CHIP, a ubiquitin ligase, plays a crucial role here. Its behavior is like a helper of the cell surface insulin receptor cycle renewal. It promotes the degradation of the insulin receptor through ubiquitination, and transfers the insulin receptor into the cell for decomposition and cyclic renewal. The brakes of the life expectancy of the body - the insulin receptor is thus "released" without braking, and CHIP also plays an anti-aging function.
The author of the article, Thorsten Hoppe, a professor at the University of Cologne, explains: "The CHIP protein has a similar function in the worms, fruit flies and human cells. This protein is increasingly stimulating our research interest."
Insufficient CHIP protein leads to premature aging
The initial results of the study were very surprising, and CHIP also performed its function in a completely different way. In particular, CHIP also promotes the degradation of misfolded and structurally damaged proteins. With age, the accumulation of protein misfolding can lead to dementia and muscle weakness. The researchers found that when the intracellular CHIP protein is severely deficient, similar degenerative diseases can be caused in both nematodes and human cells, and insulin receptor turnover is inhibited, leading to premature aging of cells.
Can the dream of Laoquan really be realized? Another author of the article, Jorg Hohfeld, a researcher from the University of Bonn, said: "In fact, it is not that simple." When the number of CHIP is too large, normal proteins are also forced to be recycled, which leads to the destruction of the body's homeostasis. However, researchers are already looking for ways to degrade the insulin receptor using CHIP, hoping to apply it to clinical treatment.
Shanghai Chuangsai Technology has excellent performance, interleukin cytokines, fetal bovine serum, electrophoresis equipment scientific instruments, raw material drug standards, chemical reagents, cell culture consumables, Shanghai Chuangsai, mass products special promotions, welcome to inquire!
Sprayer agriculture is one kind of sprayers,the material is PE, the lance is plastic lance,stepless can be adjusted,it has a capacity of3L/4L/5L/8L,the working pressure is from2.2 to 2.7pa .it has high corrosion resistant and durable and different color can be offer.It can be used for agriculture.It's very convenience to be used. We have many advantages over other products.First of all, we are very stricted in controling over the raw materials,sencondly,we have more than 20 years experience in mold translation.thirdly,we will carry out a complete inspection of each product, we have a complete set of testing equipment to ensure that each product to the hands of customers have no quality problems.The effect of fog water is very good, it can also be spray straight line.Meanwhile the size of the atomization can be mediated,also there's an exhaust valve in it, When the pressure is out of range, it can protect your safety. Sprayer Agriculture has already been the daily tool for people to make agriculture better.Sprayer Agriculture has better quality and better drainage.Sprayer Agriculture can also used on routine disinfection.It will help your daily life more convenience,more safe.
Sprayer Agriculture,Agricultural Spraying Equipment,Farm Sprayer,Disinfectant Spray Machine
YUYAO ZHENGYU SPRAYER FACTORY , https://www.zysprayer.com